Magnesium can help with depression, bone strength, cardiovascular health, insulin and blood sugar control, and it is nature’s muscle relaxer. An article appearing in Hospital Practice (April 30, 1993;79-92) had a few things to say about magnesium. Magnesium is an important cofactor in 300+ chemical reactions in the human body. It is important for ATP synthesis (cellular energy), and is found in tissues with high metabolic activity. The heart, liver, brain and kidneys all have the highest intracellular concentrations of magnesium.