Some potential causes for swelling of one hand (asymmetric swelling):  Systemic causes include early-onset RA (Rheumatoid Arthritis), OA (osteoarthritis), polymyalgia rheumatica, sarcoidosis, Kawasaki and Takayasu diseases, and psoriatic and juvenile arthritis. Rheumatoid factor-seronegative disease is associated with inflammatory bowel disease, ankylosing spondylitis (AS), lupus, scleroderma, and dermatomyositis. Infectious arthritis can result from surgical or gastrointestinal infection, rheumatic fever, gonorrhea, tuberculosis, endocarditis, Lyme disease, intravenous drug use, or RA (Rheumatoid Arthritis) …Read More